What significant event punctuates the tragic ending of "Faust"?

In "Faust," the tragic ending is significantly punctuated by Gretchen's descent into madness. This deterioration highlights the profound consequences of Faust's pact with Mephistopheles and showcases the devastating impact of ambition and desire on human lives. Gretchen, who is initially portrayed as a pure and innocent character, is ultimately consumed by guilt and despair due to the ramifications of her relationship with Faust, leading to her tragic downfall. Her madness symbolizes not only personal tragedy but also a larger commentary on the moral and existential struggles faced by individuals when they diverge from their moral compass in pursuit of forbidden knowledge or personal gain. This event serves as a critical reflection on themes of love, guilt, and the human condition, making it a powerful and poignant conclusion to the narrative.